Biochemistry 118

Sophomore Seminar

A Human Genome Stained by Fluourescent in Situ Hybridization

Genomics & Medicine

Doug Brutlag

Seminar Description

In this seminar we will discuss the kind of knowledge we have gained from sequencing human genomes and the implications of such knowledge for medicine and biomedical research. We will discuss novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. We will discuss personal genomics and how it can be used to improve health and well being. We will also discuss the social and ethical implications of genetic information such as privacy, discrimination and insurability.

The course will be of interest to students who plan to major in biology or human biology, especially premedical students and biology majors who use molecular biology methods. It will also be useful to those interested in health care policy, intellectual-property rights and ethical issues. Homework will include using genome and disease databases to determine the function of genes involved in disease. There are no prerequisites for this course.

 

Recommended Text Books

A Primer of Human Genetics 1st edition is not required for the course but it provides an excellent introduction to the material discussed including basic genetics and genomics used in medicine and research. This book would also be a good reference book for those continuing to work in this field.

A Primer of Human Genetics by Greg Gibson

A Primer of Human Genetics

Amazon

An Elementary Introduction to Genetics, Genomics and Medicine

This free, downloadable book covers the essential introductory material that every student should know before taking this course.

Genetics Home Reference

Genetics Home Reference Handbook

The End of Illness by David Agus

A layman's introduction to personal genomics

The End of Illness

Amazon

My Beautiful Genome by Lone Frank

This entertaining and enlightening book is readable by all and is the author's story of the impact of hte knowledge of her genome.

my beutiful genome

You Tube Video of Lone Frank

Amazon

 

 

 

Seminar Topics and Slide Links

Topics

Slide Links

Introduction to Genomics and Medicine

Slides

Diseases and Disease Databases

Slides

Sequencing the Human Genome

Slides

Finishing the Human Genome Sequence

Slides

Next Generation Sequencing

Slides

Genome Databases

Slides

Bioinformatics and Functional Genomics

Slides

Sequence Variations in the Human Genome

Slides

Structural Variations in the Human Genome

Slides

Discovering Variations Associated with Disease

Slides

Personal Genomics

Slides

Stem Cells

Slides

Stem Cell Therapies

Slides

Gene Expression and Cancer Diagnostics

Slides

MicroRNA Regulatory Networks

Slides

Epigenetics

Slides

Drug Discovery

Slides

Pharmacogenomics

Slides

Bibliographic Search

Slides

Ethical and Societal Issues

 

 

HomeWork Projects

Oral Case Presentation of a Mendelian Disease

Functional Analysis of a Human Gene

Genome-Wide Association Study Research Project

Disease Causing Mutations in a Mendelian Gene Project

Stem Cell Therapy Research Project

Final Project for Course

Final Projects Previously Submitted for the Seminar

1999 2000 2001 2002

2002 Bing Overseas Program

2003 2004 2005 2007

2008 Autumn

2008 Winter

2009 Autumn

2009 Winter

2010 Autumn

2011 Winter

2012 Spring

2012 Autumn

2013 Autumn

2014 Autumn

Case Presentations in the course.

2008 Autumn

2009 Winter

2009 Autumn

2010 Autumn

2011 Winter

2012 Autumn

2012 Winter

© Doug Brutlag 2015

*** Web Page last updated August 15, 2015 ***