Genomics & Medicine

Doug Brutlag

Seminar Description

In this seminar, we will discuss the kind of knowledge we have gained from sequencing human genomes and the implications of such knowledge for medicine and biomedical research. We will discuss novel diagnoses and treatment of diseases, including stem cells, gene therapy and rational drug design. We will discuss personal genomics and how it can be used to improve health and well being. We will also discuss the social and ethical implications of genetic information such as privacy, discrimination and insurability.

The course will be of interest to students who plan to major in biology or human biology, especially premedical students and biology majors who use molecular biology methods. It will also be useful to those interested in health care policy, intellectual-property rights and ethical issues. Homework will include using genome and disease databases to determine the function of genes involved in disease. There are no prerequisites for this course.

Recommended Text Books

A Primer of Human Genetics 1st edition is not required for the course but it provides an excellent introduction to the material discussed including basic genetics and genomics used in medicine and research. This book would also be a good reference book for those continuing to work in this field.

A Primer of Human Genetics by Greg Gibson

Amazon

An Elementary Introduction to Genetics, Genomics and Medicine

This free, downloadable book covers the essential introductory material that every student should know before taking this course.

Genetics Home Reference Handbook

The End of Illness by David Agus

A layman's introduction to personal genomics

Amazon

My Beautiful Genome by Lone Frank

This entertaining and enlightening book is readable by all and is the author's story of the impact of the knowledge of her genome.

You Tube Video of Lone Frank

Amazon

Seminar Topics and Slide Links

Topics	Slide Links
Introduction to Genomics and Medicine	Slides
Diseases and Disease Databases	Slides
Sequencing the Human Genome	Slides
Finishing the Human Genome Sequence	Slides
Next Generation Sequencing	Slides
Genome Databases	Slides
Bioinformatics and Functional Genomics	Slides
Sequence Variations in the Human Genome	Slides
Structural Variations in the Human Genome	Slides
Discovering Variations Associated with Disease	Slides
Personal Genomics	Slides
Stem Cells	Slides
Stem Cell Therapies	Slides
Gene Expression and Cancer Diagnostics	Slides
MicroRNA Regulatory Networks	Slides
Epigenetics	Slides
Drug Discovery	Slides
Pharmacogenomics	Slides
Bibliographic Search	Slides
Ethical and Societal Issues

HomeWork Projects

Oral Case Presentation of a Mendelian Disease

Functional Analysis of a Human Gene

Genome-Wide Association Study Research Project

Disease Causing Mutations in a Mendelian Gene Project

Stem Cell Therapy Research Project

Final Project for Course

Final Projects Previously Submitted for the Seminar

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2002 Bing Overseas Program

2003 2004 2005 2007

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2010 Autumn

2011 Winter

2012 Spring

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2013 Autumn

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2015 Autumn

Case Presentations in the course.

2008 Autumn

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2009 Autumn

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2012 Autumn

2012 Winter

© Doug Brutlag 2015

*** Web Page last updated September 7, 2015 ***