Biochemistry 118

Sophomore Seminar

Hematopoetic Stem Cells

Genomics & Medicine

Stem Cell Therapies

Doug Brutlag

Seminar Resources

Stem Cell Therapies Slides

Recent Literature Reviews

Other Literature References

Stem cell therapy recipient champions the research January 19, 2012

Reprogramming of human somatic cells to pluripotency with defined factors Park et al, (2008) Nature 451, January 10, pp 141- 147.

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors Takahashi et al. (2007) Cell 131, 861-872.

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells Yu et al, (2007) Science 318, 1917.

Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells Yamanaka, REVIEW (2007) Cell Stem Cell 1. July 2007 pp 39- 49.

Stem Cell Niche: Structure and Function. Li and Xie (2005) Annual Review of Developmental Biologyh 21, p 606-663.

Stem Cell Therapeutics. Singrec et al. 2008 Stem Cells Vol 1 pp. 313-328.

Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Fan et al. (2008) PNAS 105, 16266-16271

Current Stem Cell Clinical Trials

Front Line Video on Stem Cells and Parkinsons (2009)

My Father, My Brother and Me

Therapeutic Studies

Paralysed man walks again after stem cell transplant

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Soldner (2009) Cell. 2009 Mar 6;136(5):964-77.

Replacing an Immune System Gone Haywire Jennifer Couzin-Frankel (2010) Science 12 February 2010: Vol. 327. no. 5967, pp. 772 - 774

The Leading Edge of Stem Cell Therapeutics Singer et al (2008) Annu. Rev. Med. 2007. 58:313–28

The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases Shizuru, J.A (2009) Chapter 20 in Thomas' Hematopoetic Cell Transplantation, Wiley-Blackwell. ISBN 978-1-4051-5348-5

Rapid Reconstitution of Antibody Responses Following Transplantation of Purified Allogeneic Hematopoietic Stem Cells Linderman and Shizuru (2011) J Immunol. 2011 Apr 1;186(7):4191-9

Purified hematopoietic stem cell allografts reconstitute immunity superior to bone marrow. Tsao et al. (2009) Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3288-93.

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases Weissman and Shizuru (2008) Blood. 2008 Nov 1;112(9):3543-53.

Long-Term Outcome of Patients with Metastatic Breast Cancer Treated with High-Dose Chemotherapy and Transplantation of Purified Autologous Hematopoietic Stem Cells Müller et al. (2011) Biol Blood Marrow Transplant2011 Jul 20. [Epub ahead of print]

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells Lujan et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2527-32.

Lectures Available only to Stanford Students

Henry Stewart Talks

The development and evolution of human gene therapy (29 mins)  Prof. Theodore Friedmann  –  University of California San Diego, USA

Human hepatocyte isolation for clinical transplantation (43 mins)  Prof. Stephen Strom  –  Karolinksa Institute, Sweden

Stem Cells and Regenerative Medicine (26 mins)  Prof. Dame Julia Polak  –  Tissue Engineering and Regenerative Medicine Centre, Imperial College London, UK and
Dr. Anne Bishop  –  Tissue Engineering and Regenerative Medicine Centre, Imperial College London, UK

Clinical Potential of Stem Cells (41 mins)  Prof. John Martin  –  Centre for Cardiovascular Biology and Medicine, University College London, UK

Genes and Cells Therapy (11 mins) Prof. Nagy Habib  –  Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Imperial College London, UK

Stem Cell Therapy for the Treatment of Heart Failure (39 mins)  Dr. James Willerson  –  University of Texas Health Science Center at Houston, USA

Stem Cell Biology and Neurodegenerative Diseases (43 mins)  Dr. Ronald McKay  –  Laboratory of Molecular Biology, NINDS, USA

Vascular Tissue Engineering (35 mins)  Prof. Robert Nerem  –  Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, USA

Cartilage Stem Cells: Tools for Joint Repair? (17 mins)  Prof. Charles Archer  –  School of Biosciences and Cardiff Institute of Tissue Engineering and Repair, Cardiff University, UK

Medical Grand Rounds

Joseph Wu, Stanford Cardiology – iPSC for modeling cardiovascular disease

Robert Negrin, Stanford Bone Marrow Transplantation – Allogenic Hematopoietic Cell Transplantation Today and Tomorrow

Ross Levine, Professor of Medicine, Weill Cornell - –Genetics and therapy of Acute Myeloid Leukemia

Rainer Storb, Director of Transplantation, Fred Huntchinson, - Allogeneic Hematopoietic Cell Transplantation

Kathleen Poston, Asst. Professor of Neurology, Stanford. Parkinson’s Disease: Revisiting Classic Motor and Non-Motor Symptoms with Neuroimaging

Joy Wu - Bone and Blood: The role of osteoblasts in hematopoiesis

TRAM Symposium Lectures

Judith Shizuru - Evolving the Field of Blood Stem Cell Transplantation

Hiro Nakauchi -Generation of Cells and Organs from IPS Cells